Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades
Area of expertise and the Healthcare Provider’s contribution to care for patients within the MetabERN Network
APHP-Necker is a paediatric and adult university hospital (70% activity for child health), with:
- 600 beds
- 700 medical staff
- 3 200 paramedical staff
- 62000 hospitalisations per year
- 74000 emergency consultations
- 2400 births
- 250 paediatric and adult organ transplants performed
- 100 000 imaging analyses
- 140 million laboratory analyses
Specialised medical activities are closely linked with 32 centres for rare diseases and 22 research units staffed by 600 scientists. IMAGINE, and INEM provide the infrastructures to integrate research with clinical care. APHP-Necker is involved in one thousand peer-reviewed publications per year. The Laennec project was launched in 2012.
The IMD centre sees over 1300 patients with just under 300 new diagnoses per year (children and adults). 5% of consultations are from abroad. APHP-Necker collaborates with other national centres and has been central in establishing the IMD national network “filiere de santé maladies rares”.
APHP-Necker will make important contributions to the IMD ERN (MetabERN) in the following areas:
- Registries and data collection
- Expertise in multidisciplinary care with specialised paediatric services
- Specialised laboratory testing facilities
- Good practice guidelines
- Education and training
- Research and development
Specific treatments and interventions provided by the HCP
APHP-Necker provides the following specific treatments and interventions:
- Expertise in multiple reeducations, palliative care, ethical and cultural difficult situations
- Inborn errors of metabolism that respond to dietary therapy (therapeutical education)
- Cookery classes
- Examples of IEM that respond to treatment with cofactors or vitamins
- Hemodialysis, -filtration
- Corticoids in acute episodes of inherited metabolic diseases
- Surgery of focal hyperinsulinism and anti-mTOR in hyperinsulinism
- Small molecules
- Enzyme replacement therapy
- Organ transplantation for children and adults
- Inhibition of substrate synthesis
- Depletion of accumulated substrate
- Gene therapy
- “Hospitalisation A Domicile” (HAD, at home hospitalization service)
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Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades
Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, Paris, Francia