The metabolism of complex molecules and organelles is the object of two modules (Module 9 and 10). Module 9 is focused on the lysosome, providing an insight into its biology and its different metabolic functions, including a central role in the regulation of cellular metabolism. Autophagy and its pivotal role in preserving the normal cell function, is also discussed. From a clinical point of view, the module is centred on glycosphingolipidoses, the most common lysosomal storage diseases. In particular, Gaucher disease is chosen as a prototype of this group of disorders as it is relatively common and represents a treatable metabolic disease.
Authors: Hans Aerts, François Eyskens
