
Sugar and energy metabolism is the object of three modules (Modules 3, 4 and 5). Module 5 has a particular focus on some clinical aspects of IMDs associated to alterations in these important pathways. Specifically, hypoglycemia and how to detect several underlying IMDs that give rise to it, are described. In addition, the metabolism of lactate, the terminal product of anaerobic glucose metabolism, and the related lactic acidemia and acidosis are addressed, also highlighting the methods to specifically recognize lactic acidemia caused by IMDs. Â The Module also deals with galactosemia, an inborn error of the metabolism of galactose/lactose that manifests with life-threatening liver disease and E. Coli sepsis in early infancy. The use of dietary therapy and the difficulty in the treatment of some clinical features, such as neurological and bone manifestations and ovarian failure, are particularly explored.
Authors: Peter Witters, Mireia del Toro, Annet Bosch, Isabel Rivera, Estela Rubio
The Diagnostic, Clinical and Therapeutic Education Programme on Inherited Metabolic Disorders. Module 05: Sugars & energy metabolism (III) made available on https://metab.ern-net.eu/education-programme/ and organized by MetabERN – European Reference Network for Hereditary Metabolic Disorders is accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) to provide the following CME activity for medical specialists. Only those e-learning materials that are displayed on the UEMS-EACCME® website have formally been accredited.Â
Only those e-learning materials that are displayed on the UEMS-EACCME® website have formally been accredited.
Through an agreement between the European Union of Medical Specialists and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 Credits™. Information on the process to convert EACCME® credits to AMA credits can be found at https://edhub.ama-assn.org/pages/applications.

This Module has been awarded with 2,5 ECMEC® credits