2.2

Disorders of lipoprotein metabolism

This group of disorders includes different subgroups such as hypercholesterolemias, hypertriglyceridemias, mixed hyperlipidemias, disorders of high-density lipoprotein metabolism and disorders with decreases low-density lipoprotein or tryglicerides. These disorders have been classified depending on the type of lipid anomalies that can be observed in the blood. These disorders are often accompanied by comorbidities such as obesity, hyperglycemia, hypertension and might lead to atherosclerosis and issues with cardiovascular health.

2.2.a

Hypercholesterolemias

LDL receptor deficiency (Familial hypercholesterolemia) LDL receptor adaptor protein 1…
2.2.b

Hypertriglyceridemias

Lipoprotein lipase deficiency (Hyperlipoproteinemia type 1A) Apolipoprotein C2 deficiency (Hyperlipoproteinemia…
2.2.c

Mixed hyperlipidemias

Apolipoprotein E deficiency (Dysbetalipoproteinemia; hyperlipoproteinemia type 3) Apolipoprotein E superactivity…
2.2.d

Disorders of high-density lipoprotein (HDL) metabolism

Lecithin:cholesterol acyltransferase deficiency (Norum disease, severe; fish-eye disease, milder) Tangier…
2.2.e

Disorders with decreased low-density lipoprotein (LDL) and/or triglycerides

Apolipoprotein B deficiency PCSK9 deficiency (Familial hypercholesterolemia type 3) Angiopoietin-like…
2.2.f

Other disorders of lipoprotein metabolism

Very low-density lipoprotein receptor deficiency Hereditary apolipoprotein A1-related amyloidosis Elevated…

Subnetworks

PD 1 1

PD

Peroxisomal and lipid-related disorders

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